Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA

Abstract Background Gene regulation in eukaryotes is a complex process entailing the establishment of transcriptionally silent chromatin domains interspersed with regions of active transcription.Imprinted domains consist of clusters of genes, some of which exhibit parent-of-origin dependent monoallelic expression, while others are biallelic.The Kcn

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Greedy Action Selection and Pessimistic Q-Value Updating in Multi-Agent Reinforcement Learning with Sparse Interaction

Although multi-agent reinforcement learning (MARL) is a promising method for learning a collaborative action policy, enabling each agent to accomplish specified tasks, MARL has a problem of exponentially increasing state-action space.This state-action space can be dramatically reduced by assuming sparse interaction.We previously proposed three meth

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